|
KMID : 1011620190350060664
|
|
Korean Journal of Food and Cookey Science
2019 Volume.35 No. 6 p.664 ~ p.671
|
|
|
Inhibitory Effects of Ecklonia cava Ethanol Extract against Noroviruses Causing Foodborne Diseases
|
|
Kim Hyo-Jin
Im Chae-Yeon
Chung Mi-Sook
|
|
|
Abstract
|
|
|
Purpose: Human norovirus infections are a significant cause of viral foodborne outbreaks worldwide. The purpose of this study was to determine the inhibitory effects of Ecklonia cava ethanol extract against human norovirus surrogates, feline calicivirus-F9 (FCV) and murine norovirus-1 (MNV).
Methods: Ecklonia cava was extracted with 70% ethanol and then lyophilized. The inhibitory effects of the extract against the foodborne viral surrogates were analyzed using time-of-addition plaque assays. The glutathione level and antioxidant effects were determined.
Results: In the pretreatment and cotreatment of the virus, the Ecklonia cava ethanol extract exhibited inhibitory effects against FCV and MNV in a dose-dependent manner. The FCV- or MNV-infected cells treated with 100 μg/mL showed significantly increased glutathione levels, compared to those in the virus-infected cells. Ecklonia cava also exhibited DPPH radical scavenging activity and ferric ion reducing activity.
Conclusion: Ecklonia cava can be developed as a novel algae-derived anti-norovirus food material against foodborne viral diseases.
|
|
|
KEYWORD
|
|
|
murine norovirus, feline calicivirus, Ecklonia cava, antiviral activity, antioxidant activity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|